References

Collagen Maturation

1. Maquart FX, Bellon G, Gillery P, Wegrowski Y, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Connect Tissue Res. 1990;24(2):107-20.
2. Bonte F, Dumas M, Chaudagne C, Meybeck A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med. 1994 Apr; 60(2) :133-5.
3. Lu L, Ying K, Wei S, Fang Y, Liu Y, Lin H, Ma L, Mao Y. Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts. Int J Dermatol. 2004 Nov;43(11):801-7.
4. Bonte F, Dumas et al. Comparitive activity of asiaticoside and madecosside on type I and type II collagen synthesis by cultured human fibroblasts. Ann Pharm Fr 53 (1) 38-43, 1995.
5. Tenni R, et al. Effect of the triterpenoid fraction of Centellaasiatica on macromolecules of the connective matrix in human skin fibroblast cultures. Ital J Biochem. 1988;37(2):69-77.
6. Sunilkumar, Parameshwaraiah S, Shivakumar HG. Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats. Indian J Exp Biol. 1998 Jun;36(6):569-72.
7. Maquart FX, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 1999 Jun;9(4):289-96.
8. Puig A, Anton GMJ and Mangues M. A new Decorin-like Tetrapeptide for Optimal Organization of Collagen Fibres. IFSCC Magazine, Vol10, No 4 309, 2007.
9. *AtiyehBS ;Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods Aesth Plast Surg 31, 468, 2007.

Hydration

1. Sawada Y, Sone K, Hydration and occlusion treatment for hypertrophic scars and keloids, Br Journ Plast Surg 45, 599, 1992.
2. Niessen FB, Letter; Effectiveness of Silicone Sheets in the Prevention of Hypertrophic Breast Scars, Ann Plast Surg, 54, 1997.
3. Mustoe et al; International clinical recommendations on scar management. Plast Reconstr Surg. 2002 Aug; 110(2):560-71. Review.
4. Sawada Y, Urushidate S, Nihei Y: Hydration and occlusive treatment of a sutured wound. Ann Plast Surg 41:508, 1998
5. Chan KY ; Silicone Gel in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound - etal; Plast Reconstr Surg 2005
6. Gold etal Prophylactic Use of Topical Silicone Gel Sheets Following a Surgical Procedure in an Office Setting –; Dermatologic Surg 2001
7. Sproat JE etal Hypertrophic sternal scars: Silicone gel sheet versus Kenalog injection treatment.-;. Plast. Reconstr. Surg. 1992.
8. Ahn etal Topical silicone gel for the prevention and treatment of hypertrophic scar.; Arch. Surg, 1991.
9. Cruz-Korchin, N Effectiveness of silicone sheets in the prevention of hypertrophic breast scars. Ann. Plast. Surg., 1996.
10. LeVier, R etal What is silicone? Plast. Reconstr. Surg.; 1993.
11. Quinn, K. J Silicone gel in scar treatment. Burns 1987.
12. Pekins, K. etal Silicone gel: A new treatment for burn scars and contractures.;Burns 1982.
13. Quinn, K etal Non-pressure treatment of hypertrophic scars.; Burns,1985.
14. Niessen, F etal The use of silicone occlusive sheet (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation.; Plast. Reconstr. Surg.1998.
15. Clugston, P etal; Evaluation of silicone-gel sheeting in early wound healing of linear incisions. Ann. Plast. Surg. 34: 12, 1995.
16. MHafezi et al ;Effects of silicone gel on burn scars. Burns. 2008 Jul 29.
17. *Thomas A. Mustoe Evolution of Silicone Therapy and Mechanism of Action in Scar Management , Aesthetic Plastic Surgery March 2008
18. *Tandara & Mustoe The role of the epidermis in the control of scarring: evidence for mechanism of action for silicone gel JPRAS Aug 2008

Controlled inflammation

1. Petroni A., et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thrombosis Res., 1995; 78:151-60.
2. Hertog M., et al., Dietary antioxidant flavonoids and risk of coronary heart disease: the Zupthen elderly study. Lancet 1993; Oct. 23; 342:1007-11.
3. Beauchamp K1, et al1. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil Nature 437, 45-46 (1 September 2005).
4. de la Puerta, R, Martinez-Dominguez, E., et al. Effect of minor components of virgin olive oil on topical anti-inflammatory assays. Z Naturforsch 2000 Sep-Oct; 55 (9-10):814.
5. Tranter, H.S.; Tassou, S.C.; Nychas, G.J. "The effect of the olive phenolic compound, oleuropein, on growth and enterotoxin B production by Staphylococcus aureus. Journal of Applied Bacteriology 74:253-259, 1993.
6. Pasquale, A.D.; Monforte, M.T.; Calbro, M.L. "HPLC analysis of oleuropein and some flavonoids in leaf and bud of Olea Euripaea L. II Pharmaco 46(6):803-815, 1991.
7. Privitera, J.R., Olive Leaf Extract: A New/Old Healing Bonanza for Mankind (Covina, CA: NutriScreen, Inc.), 1996.
8. Fleming, H.P.; Walter, W.M.; Etchells, J.L. "Antimicrobial properties of oleuropein and products of its hydrolysis from green olives." Microbiology 26(5):777-782, Nov. 1973.
9. Visioli F and Galli C, Oleuropein protects low density liproprotein from oxidation, Life Sciences, 1994; 55(24), 1965-71.
10. Puel C Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Br J Nutr. 2004; 92(1):119-27

Support

1. Sommerlad BC, Creasey JM: The stretched scar: A clinical and histological study. Br J Plast Surg 3 1:34, 1978
2. Elliot D, Cory-Pearce R, Rees GM: The behaviour of presternal scars in a fair-skinned population. Ann R Coll Surg Engl 67:238, 1985
3. Meyer M, McGrouther DA: A study relating wound tension to scar morphology in the presternal scar using Langers technique. Br J Plast Surg 44:291, 1991
4. Reiffel RS: Prevention of hypertrophic scars by long term paper tape application. Plast Reconstr Surg 96:1715, 1995
5. *Atkinson et al: A Randomized Controlled Trial to determine the Efficacy of Paper Tape in Preventing Hypertrophic Scar Formation In Surgical Excisions that Travers Langers Skin Tension Lines Plastic & Reconstr Surg Nov 2005.